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KMID : 0378019780210020089
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New Medical Journal
1978 Volume.21 No. 2 p.89 ~ p.93
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Red Cell GPT Enzyme Polymorphism in Korean
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Abstract
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Glutamic-pyruvic transaminase (GPT) or alanine aminotransferase (E. C. 2.6.1.2) has an important function in the interconversion of carbohydrate and amino acid metabolic pathways, otherwise red blood cell has two types of enzyme which exist in both cytoplasmic (soluble) and mitochondrial (residual) forms. In nature red cells, only the soluble form is present, and also recently genetic polymorphism of this enzyme was detected by starch-gel electrophoresis of human red cell lysates by the Chen. There is three common phenotypes representing the homozygous and heterozygous expression of two autosomal alleles, called GPT1, and GPT2. This paper concerns the phenotypic distribution of polymorphic red cell GPT enzyme systems among Koreans. 110 cases which were hematologic and biochemically normal sample were used. By the Chen´s method, starch-gel electrophoresis was performed and the results obtained were; 1. GPT1: 30.2% (33/110 cases) 2. GPT2-1: 56.1% (62/110 cases) 3. GPT2: 13.7%(15/110 cases)
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KEYWORD
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